Your Genes, Folate, and Human Health 

Folate is one of the most essential nutrients needed during rapid cell division and growth. It is no surprise that pregnancy doubles the need for dietary folates. 

Folate coenzymes play a vital role in metabolism through two different pathways: the synthesis of DNA from its precursors (purines/thymidines) and the homocysteine (methionine) pathway. 

5-MTHF is needed for the conversion of homocysteine to methionine, which allows for the production of S-adenosylmethionine (known as SAMe). This is important because SAMe is the universal methyl donor. Methyl-group donation is vital to proper cell replication and differentiation and to hundreds of biochemical conversion processes, including the synthesis of serotonin, melatonin, and DNA.

MTHFR and the other methylation genes

A mutation in the MTHFR gene impacts how well the MTHFR enzyme performs. An MTHFR deficiency may lead to hyperhomocysteinemia. Several MTHFR gene mutations result in a mild to severe impairment of the activity of the MTHFR enzyme, the most characterized mutation being C677T (C677T MTHFR mutation). 

This gene mutation makes a person more susceptible to: 

• Anxiety
• Depression
  
• Neurodegenerative diseases and conditions
• Coronary heart disease
• Stroke
• Preeclampsia (high blood pressure in pregnant women)
• Birth defects including neural tube defects 

Research studies have also correlated this with demyelination of the brain and spinal cord. 

L-5-MTHF should be considered when high doses of folate are needed for Individuals who have tested homozygous with either the A1298C or C677T MTHFR mutation, or those with elevated homocysteine levels. BioOne Sciences Methylation Activation, in the form of L-5-MTHF, is the preferred form of folate supplementation.